Antibiotics
Challenges, Mechanisms, Opportunities
By Christopher Walsh, Timothy Wencewicz | Publisher: Wiley
About the book
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Editions of Antibiotics
- Hardcover
- ISBN 9781555819309
- EBook
- ISBN 9781683673316
- EBook
- ISBN 9781683670896
- EBook
- ISBN 9781555819316
Read an Excerpt
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Frequently Asked Questions
What is Antibiotics about?
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
What core themes, tropes, or subjects are explored in Antibiotics?
Medicine and Nursing > Medical specialties, branches of medicine > Pathology > Medical microbiology and virology
Where can I read a sample of Antibiotics?
You can read an official preview of the few pages here https://www.book2look.com/book/9781555819309
Is Antibiotics part of a series, and can it be read as a standalone?
Yes it is a part of series ASM Books
Who is/are the Author/s of the book Antibiotics?
Christopher Walsh, Timothy Wencewicz
Who is the Publisher of the book Antibiotics?
Wiley
What are the ISBN numbers for the physical and digital editions?
Antibiotics is available as hardcover(ISBN 9781555819309) and ebook(ISBN 9781683673316) and ebook(ISBN 9781683670896) and ebook(ISBN 9781555819316)
Where can I buy Antibiotics online or support local independent bookshops?
You can buy Antibiotics from below
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